Rev N Repair
30 g Jar
Reformulated — Now One Cream

Rev N Repair — Rapamycin + Tazarotene Anti-Aging Cream (0.05% / 0.05%)

The first physician-compounded topical that combines rapamycin — an mTOR inhibitor with emerging clinical evidence for reversing cellular skin aging — with tazarotene, the most potent prescription retinoid. One 30 g jar. One step before bed.

Prescription-only

Pricing confirmed at consult Compounded fresh per order

What Is Rev N Repair?

Rev N Repair is a prescription-compounded topical cream that delivers two clinically meaningful anti-aging actives in one daily step: rapamycin 0.05% and tazarotene 0.05%, suspended in Medisca’s VersaPro cream base. It targets the two mechanisms that drive visible skin aging — cellular senescence and declining collagen turnover — through complementary pathways that no over-the-counter product can replicate.

This is the reformulated Rev N Repair. The original version shipped as a kit with a separate moisturizing cream that patients had to layer on top. Patients asked for something simpler. The new single-jar formulation puts both actives into one step, fixes the layering-order mistakes that blunted the original’s results, and upgrades the vehicle to a pharmaceutical-grade base.

The Science Behind Rev N Repair

Tazarotene and Rapamycin work on completely different biological pathways — which is precisely why they are so powerful together.

RAPAMYCIN 0.05%

The Unique Ingredient

Rapamycin (also called sirolimus) is an mTOR inhibitor originally approved for organ-transplant patients. Over the past decade, longevity researchers have identified it as one of the most studied molecules in geroscience — the science of aging.

In 2019 and again in 2022, researchers at Drexel University College of Medicine published the first human trials of topical rapamycin on aged skin. The results were striking:

• Reduction in the senescence marker p16INK4A — a protein that accumulates in old, dysfunctional skin cells and drives inflammation.
• Increased collagen VII at the dermal-epidermal junction — the structural protein that anchors young-looking, firm skin.
• Visible improvement in wrinkling, skin tone, and overall appearance after 6–8 months of application.
• Minimal systemic absorption — blood levels of rapamycin were undetectable or negligible in trial participants.

Unlike retinoids, which stimulate cell turnover, rapamycin works upstream by telling the skin’s existing cells to behave younger. It doesn’t push dead cells off the surface — it tells the living ones to stop acting old. No over-the-counter product on the market contains topical rapamycin. It requires a prescription and a compounding pharmacy.

TAZAROTENE 0.05%

The Most Potent Prescription Retinoid

Tazarotene is the strongest FDA-approved topical retinoid. In dermatology it’s best known for acne and psoriasis, but the same mechanism that clears breakouts — selective binding of retinoic acid receptors beta and gamma — is what makes it exceptional for photoaging.

Peer-reviewed dermatology studies show tazarotene produces measurable improvements in:

• Fine and coarse wrinkles — from UV-driven collagen loss
• Mottled hyperpigmentation and lentigines (sun spots)
• Elastosis — the yellow, thickened texture of chronic sun damage
• Overall skin tone evenness and radiance

Tazarotene typically outperforms tretinoin in head-to-head photoaging studies — including at equivalent concentrations — because of its receptor selectivity and higher potency.

Medisca VersaPro Cream Base

Pharmaceutical-Grade Vehicle

VersaPro is a pharmacist-preferred compounding vehicle engineered by Medisca — one of the largest compounding-pharmacy suppliers in North America — specifically for holding prescription actives stably at physiologic pH. It’s a non-comedogenic, emulsified cream with a lightweight skin feel.

Why it matters: compounding actives like rapamycin and tazarotene into a consumer-grade moisturizer often degrades them within weeks. A pharmaceutical base preserves potency, spreads evenly, and minimizes irritation — so what you paid for actually reaches your skin.

Not sure how rapamycin compares to retinol or tretinoin? Read the full comparison →

Why Combine Rapamycin and Tazarotene?

Most anti-aging routines attack skin aging from one angle: retinoids push surface turnover, peptides try to signal collagen, antioxidants mop up free radicals. Rev N Repair attacks aging from two upstream mechanisms simultaneously:

Complementary, not overlapping

• Rapamycin clears the old. It inhibits mTORC1, which reduces the burden of senescent cells — the zombie cells that leak inflammatory signals into surrounding tissue and drive visible aging.
• Tazarotene rebuilds the new. It triggers keratinocyte turnover and fibroblast activation, stimulating fresh collagen and reorganizing the dermal matrix.
• Together they compound. Clearing senescent cells creates the biological “room” for tazarotene-driven regeneration to actually stick. Using either alone leaves money on the table.

Who Rev N Repair Is For

Rev N Repair is appropriate for adults who want a physician-supervised, prescription-grade topical for:

• Photoaging — fine lines, crow’s feet, forehead lines, peri-oral lines
• Sun damage — mottled pigmentation, sun spots, lentigines
• Uneven skin tone and loss of radiance
• Textural aging — elastosis, crepey texture, loss of firmness
• Prevention — adults in their 30s and 40s who want to get ahead of visible aging
• Longevity-minded patients already taking oral rapamycin or following geroscience-informed protocols, who want the same molecule working locally on the organ they see in the mirror

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How to Use Rev N Repair

Rev N Repair is used once nightly as part of a simple three-step evening routine. The key is to start slowly — retinoids and rapamycin both have adjustment periods, and going too hard too fast causes unnecessary irritation.

1. Cleanse. Wash with a mild, non-stripping cleanser. Pat dry and wait 10–15 minutes for skin to fully dry — applying retinoids to damp skin increases irritation.
2. Apply Rev N Repair. Use a pea-sized amount for the entire face. Start at 2–3 nights per week for the first 2 weeks. Increase to every other night in week 3–4. Move to nightly only if well tolerated.
3. Moisturize (optional but helpful in the adjustment period). Layer a simple ceramide-rich moisturizer on top if you experience any dryness or flaking.

Every morning: apply broad-spectrum SPF 30 or higher. Retinoids increase photosensitivity; sunscreen is non-negotiable with this product.

Who Formulated Rev N Repair

David Mahjoubi, MD

Board-Certified Anesthesiologist Founder, Dr. David Wellness President, American Board of Ketamine Physicians

Dr. Mahjoubi developed Rev N Repair out of his own longevity practice — for patients who wanted to apply a geroscience-informed anti-aging protocol to the one organ they see every morning. Every jar is compounded at a licensed U.S. pharmacy and dispensed only after a brief telehealth intake.

Medically reviewed by David Mahjoubi, MD — Board-Certified Anesthesiologist, Founder of Dr. David Wellness. Last reviewed: April 14, 2026.

Start With a Brief Telehealth Consult

Rev N Repair is prescription-only. Start with a quick intake with Dr. Mahjoubi, MD — he’ll confirm the formula is right for your skin and medical history, then your 30 g jar is compounded fresh and shipped to your door.

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