Rapamycin (Sirolimus) Topical Facial Cream (20 grams)

Rapamycin topical facial cream is arguably the most well studied and proven skin longevity treatment. Scientifically shown to address the root cause of skin aging on a cellular level, Dermatologists agree it should be part of every person’s skin care regimen. The IV Healing Spa has crafted it as a daily moisturizer to protect your skin’s most vulnerable areas: the face, hands, upper chest, and neck.

The biologic effects of topical Rapamycin are the following:

• Improved skin photoaging and skin tone
• Decreased find wrinkles
• Increased dermal volume
• Reduced sagging of the skin

The 3 primary ways Rapamycin slows the aging of the skin cell are the following:

• By reducing the cellular effects of photoaging from the sun’s UV rays.
• Increasing collagen protein. Collagen is a building block for the skin, providing structure, strength, and elasticity. As people age, their bodies produce less collagen, which can lead to wrinkles and dry skin.
• Decreasing levels of p16 protein, a key marker of skin cell aging. Skin that has lower levels of p16 has fewer senescent cells, which are associated with skin wrinkles.

We cannot see cellular damage until premature aging starts. This can happen even with sunblock applied to our skin. Rapamycin applied to the skin can help reduce cellular damage associated with conditions like sun burns or overexposure, accelerated aging from tanning beds, eczema, psoriasis, or other inflammatory skin disorders.

Transparency is key to building trust, and that’s why we provide access to our certificate of analysis, or COA. Certificate of Analysis for Rapamycin (Sirolimus).

Here are some other benefits from Rapamycin:

1. Anti-cancer Properties: Rapamycin has shown promise in inhibiting the growth of cancer cells. It does this by targeting a protein called mTOR (mechanistic target of rapamycin), which is involved in cell growth and division. Inhibition of mTOR can lead to the suppression of tumor growth in certain types of cancer.
2. Anti-aging Effects: Some research suggests that rapamycin could have anti-aging properties. By inhibiting mTOR, rapamycin may slow down cellular senescence (the process of aging) and extend lifespan in various organisms.
3. Neuroprotective Effects: There’s emerging evidence suggesting that rapamycin might have neuroprotective properties. It could potentially be useful in treating neurodegenerative diseases like Alzheimer’s and Parkinson’s by promoting neuronal health and reducing neuroinflammation.
4. Cardioprotective Effects: Rapamycin has been studied for its potential to protect the heart against damage from conditions like ischemia-reperfusion injury and cardiac hypertrophy. It may help in preventing adverse cardiac remodeling and improving heart function in certain cardiovascular diseases.

However, it’s important to note that rapamycin may not be for everyone. Topical use rarely if ever has side effects associated with it. However, some individuals may experience the following:

• Skin Irritation: One of the most common side effects of topical rapamycin is skin irritation. This may manifest as redness, itching, burning, or stinging at the application site.
• Dryness and Peeling: Some individuals may experience dryness and peeling of the skin with topical rapamycin use. This side effect is often mild to moderate and may improve with continued use or adjustment of the dosage.
• Sensitivity to Sunlight: Topical rapamycin can increase sensitivity to sunlight, leading to a higher risk of sunburn. It’s important to use sunscreen and protective clothing when using rapamycin topically to minimize sun exposure and reduce the risk of skin damage.
• Allergic Reactions: In rare cases, topical rapamycin may cause allergic reactions, such as rash, hives, or swelling of the face, lips, or tongue. If you experience any signs of an allergic reaction, discontinue use and seek medical attention immediately.
• Skin Discoloration: Prolonged use of topical rapamycin may cause changes in skin pigmentation, leading to areas of hyperpigmentation or hypopigmentation.
• Infection: While not common, there is a risk of developing skin infections with topical rapamycin use, particularly if the skin barrier is compromised or if the medication is contaminated.
• Systemic Absorption: Although topical rapamycin is primarily intended for local use, some absorption through the skin into the bloodstream can occur. Systemic absorption may increase the risk of systemic side effects associated with oral rapamycin, such as immunosuppression, metabolic disturbances, and an increased risk of infections or certain cancers.

If you experience any concerning symptoms or side effects while using topical rapamycin, be sure to let us know and consult your healthcare provider for further evaluation and management.

• Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925069/
• Rapamycin decelerates cellular senescence
  https://pubmed.ncbi.nlm.nih.gov/19471117/
• mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477550/